Description

β-Hydroxyleucine is a non-proteinogenic amino acid derivative characterized by a hydroxyl group on the β-carbon of the leucine side chain. This unique structural feature makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is particularly significant for the research and development of pharmaceuticals, bioactive peptides, and fine chemicals. Industries requiring high-purity chiral intermediates for asymmetric synthesis are the primary users of this specialty compound.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other peptide-based therapeutics.
• Biochemical Research: Used as a standard or reagent in metabolic pathway studies and enzymatic research involving branched-chain amino acid analogs.
• Peptide Synthesis: Employed as a modified amino acid residue in solid-phase peptide synthesis (SPPS) to introduce hydroxyl functionality, altering peptide solubility and bioactivity.
• Fine Chemical Production: Acts as a precursor for the manufacture of specialty chemicals, including ligands for asymmetric catalysis and advanced material monomers.
• Nutraceutical Research: Investigated for potential applications in metabolic research and the development of specialized nutritional supplements.

Basic Information

Product Name	β-Hydroxyleucine
CAS No.	5817-22-1
Molecular Formula	C6H13NO3
Molecular Weight	147.17 g/mol
Synonyms	β-Hydroxyleucine; (2S,3S)-2-Amino-3-hydroxy-4-methylpentanoic acid; (2S,3S)-3-Hydroxyleucine; allo-β-Hydroxyleucine; 3-Hydroxy-L-leucine; L-β-Hydroxyleucine; 2-Amino-3-hydroxy-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our β-Hydroxyleucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.