Description

4-Chloro-6-Hydrazinopyrimidine is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its reactive chloro and hydrazino substituents make it a key intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various drug candidates, particularly those with pyrimidine-based cores, such as kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators, leveraging its heterocyclic structure for biological activity.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Employed in the synthesis of specialized ligands, coordination complexes, and organic electronic materials.
• Cross-Coupling Reactions: The chloro group is amenable to palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating diverse biaryl and amino-substituted pyrimidines.
• Heterocycle Functionalization: The hydrazino group can be used to introduce further nitrogen-containing functionalities, such as triazoles and tetrazoles, via condensation or cyclization reactions.

Basic Information

Product Name	4-Chloro-6-Hydrazinopyrimidine
CAS No.	5767-35-1
Molecular Formula	C4H5ClN4
Molecular Weight	144.56 g/mol
Synonyms	6-Hydrazinyl-4-chloropyrimidine; 4-Chloro-6-pyrimidinylhydrazine; 4-Chloro-6-hydrazino-pyrimidine; 4-Chloro-6-pyrimidinamine, N-amino-; 4-Chloro-6-hydrazinylpyrimidine; 4-Chloro-6-pyrimidinehydrazine; 4-Chloro-6-aminohydrazinopyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Hydrazinopyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.