Description

n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-Methyl 1-(4-Nitrophenyl) Ester is a high-purity, protected amino acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in the synthesis of complex peptides and other biologically active molecules, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: Used in the discovery and development of new therapeutic agents, particularly in oncology and metabolic disease research.
• API Manufacturing: Serves as a crucial building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring specific glutamic acid derivatives.
• Bioconjugation: Employed in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Chemical Biology: Utilized as a tool compound or precursor in probing enzyme mechanisms and protein-protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-Methyl 1-(4-Nitrophenyl) Ester
CAS No.	5672-80-0
Molecular Formula	C20H20N2O8
Molecular Weight	416.38 g/mol
Synonyms	Z-Glu(OMe)-ONp; Cbz-L-Glutamic Acid 5-Methyl Ester 1-(4-Nitrophenyl) Ester; N-Carbobenzoxy-L-glutamic acid 5-methyl ester 1-(4-nitrophenyl) ester; (2S)-2-[(Benzyloxy)carbonylamino]pentanedioic acid 5-methyl ester 1-(4-nitrophenyl) ester; Z-L-Glutamic acid α-4-nitrophenyl ester γ-methyl ester; Z-Glu-OMe-ONp; Nα-Cbz-L-glutamic acid γ-methyl ester α-p-nitrophenyl ester; Benzyl N-[(1S)-4-methoxy-1-[(4-nitrophenoxy)carbonyl]-4-oxobutyl]carbamate
EINECS	Contact for details

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Glutamic Acid 5-Methyl 1-(4-Nitrophenyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.