Description

[Val5]-Angiotensin II is a synthetic peptide analog of the endogenous vasoconstrictor hormone, Angiotensin II, featuring a valine substitution at position 5. This modification is critical for research into the structure-activity relationships of the renin-angiotensin system and its role in cardiovascular physiology. It serves as a vital biochemical tool for pharmaceutical R&D, academic research, and diagnostic assay development, enabling studies on hypertension, heart failure, and receptor signaling pathways.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the renin-angiotensin-aldosterone system (RAAS), receptor binding, and signal transduction mechanisms.
• Pharmaceutical Development: Employed in the screening and validation of novel angiotensin receptor blockers (ARBs) and other cardiovascular drug candidates.
• Diagnostic Assays: Serves as a key component in the development and calibration of immunoassays (e.g., ELISA, RIA) for measuring angiotensin-related biomarkers.
• Cell Biology Studies: Applied in vitro to stimulate cellular responses in vascular smooth muscle cells, adrenal cells, and neurons to study physiological and pathological processes.
• Biochemical Standard: Utilized as a high-purity calibrant in analytical laboratories for method development and quality control of peptide analyses.

Basic Information

Product Name	[Val5]-Angiotensin II
CAS No.	5649-07-0
Molecular Formula	C₄₉H₇₀N₁₄O₁₁
Molecular Weight	1031.2 g/mol
Synonyms	Angiotensin II, [Val5]-; Asp-Arg-Val-Tyr-Val-His-Pro-Phe; 5-L-Valine-angiotensin II; H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH; Val5-Ang II; [Val⁵]-Ang II; DRVYVHPF
EINECS	Contact for details

Quality Control

Our [Val5]-Angiotensin II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.