Description

4-[Methyl[(2-Amino-4-Hydroxypteridine)-6-Ylmethyl]Amino]Benzoic Acid is a high-purity, specialized pteridine derivative with significant biochemical relevance. This compound serves as a critical intermediate and reference standard in the research and synthesis of folate analogs and related bioactive molecules. It is essential for pharmaceutical R&D, analytical laboratories, and fine chemical synthesis targeting metabolic pathways and enzyme inhibition studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel folate antagonists and related therapeutic agents.
• Biochemical Research: Used as a reference standard and probe in studies of dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Analytical Chemistry: Serves as a high-purity calibration standard for HPLC, LC-MS, and other chromatographic methods in quality control labs.
• Fine Chemical Synthesis: Intermediate for producing more complex pteridine-based compounds for academic and industrial research.
• Nutritional Science Research: Used in studies investigating folate metabolism and the development of analytical methods for vitamin B9 and its analogs.

Basic Information

Product Name	4-[Methyl[(2-Amino-4-Hydroxypteridine)-6-Ylmethyl]Amino]Benzoic Acid
CAS No.	5623-18-7
Molecular Formula	C16H16N6O3
Molecular Weight	340.34 g/mol
Synonyms	6-[(Methyl-p-aminobenzoyl)amino]-2-amino-4-hydroxypteridine; N-[p-[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]glutamic Acid Impurity; 4-[Methyl[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoic Acid; Methotrexate Related Compound; Aminopterin Intermediate; Pteroylglutamic Acid Derivative; Folate Analog Intermediate
EINECS	Contact for details

Quality Control

Our 4-[Methyl[(2-Amino-4-Hydroxypteridine)-6-Ylmethyl]Amino]Benzoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and synthesis. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with client requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.