Description

2,3,4,5-Tetrafluoroaniline is a high-value fluorinated aromatic amine building block, essential for introducing the tetrafluoroaniline moiety into complex molecular architectures. Its unique electronic and steric profile, imparted by the fluorine substituents, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where fluorine atoms improve metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent for introducing aniline functionality into perfluorinated aromatic systems in research and development.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for niche applications.

Basic Information

Product Name	2,3,4,5-Tetrafluoroaniline
CAS No.	5580-80-3
Molecular Formula	C6H3F4N
Molecular Weight	165.09 g/mol
Synonyms	2,3,4,5-Tetrafluorobenzenamine; 1-Amino-2,3,4,5-tetrafluorobenzene; Benzenamine, 2,3,4,5-tetrafluoro-; 2,3,4,5-Tetrafluorophenylamine; Tetrafluoroaniline; 2,3,4,5-TFA; TFA (context-specific)
EINECS	226-970-7

Quality Control

Our 2,3,4,5-Tetrafluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to light and tendency for oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	62 - 66 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.