Description

Boc-3-Nitro-L-Tyrosine is a protected derivative of the non-proteinogenic amino acid 3-nitrotyrosine, where the amine group is safeguarded by a tert-butoxycarbonyl (Boc) group. This specific chemical modification is crucial for peptide synthesis, as it prevents unwanted side reactions during the coupling process while allowing for selective deprotection under mild acidic conditions. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for studying oxidative stress, developing diagnostic tools, and synthesizing complex peptides and proteins.

Application

• Peptide Synthesis: A key protected amino acid intermediate for solid-phase and solution-phase peptide synthesis (SPPS).
• Biomedical Research: Used in the study of nitrosative stress, protein nitration, and related neurodegenerative or inflammatory disease pathways.
• Proteomics & Diagnostics: Employed in the development of assays and reagents to detect and quantify protein tyrosine nitration in biological samples.
• Chemical Biology: Serves as a precursor for synthesizing activity-based probes and other tools to investigate enzyme function.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• API Intermediate: Acts as a critical raw material in the research and development stages of novel active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Boc-3-Nitro-L-Tyrosine
CAS No.	5575-03-1
Molecular Formula	C₁₄H₁₈N₂O₇
Molecular Weight	326.30 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-3-nitro-L-tyrosine; Boc-Tyr(3-NO2)-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-hydroxy-3-nitrophenyl)propanoic acid; tert-Butoxycarbonyl-3-nitro-L-tyrosine; Boc-L-Tyrosine(3-NO2); N-Boc-3-nitro-L-tyrosine; 3-Nitro-L-tyrosine, N-Boc derivative; BOC-TYR(3-NO2)
EINECS	Contact for details

Quality Control

Every batch of Boc-3-Nitro-L-Tyrosine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and synthesis applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.