Description

Z-Tyr(Tbu)-OH is a protected tyrosine derivative, specifically the tert-butyl ether of the phenolic hydroxyl group, widely used as a crucial building block in peptide synthesis. This compound is essential for researchers and manufacturers who require precise control over side-chain reactivity during solid-phase and solution-phase peptide assembly. Its primary value lies in enabling the synthesis of complex peptides and proteins where tyrosine residues must be incorporated without interference. This makes it indispensable for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative to incorporate tyrosine residues into peptide chains, preventing unwanted side reactions.
• Solution-Phase Peptide Synthesis: Facilitates the stepwise construction of peptides in solution, particularly for shorter sequences or specialized modifications.
• Bioconjugation and Labeling: Serves as a precursor for creating tyrosine-containing linkers or tags used in antibody-drug conjugates (ADCs) or fluorescent probes.
• Research & Development: Fundamental building block in academic and industrial labs for exploring new peptide structures, studying protein function, and drug discovery.
• Custom Peptide Service Providers: A standard reagent for companies offering bespoke peptide synthesis services to the life science community.

Basic Information

Product Name	Z-Tyr(Tbu)-OH
CAS No.	5545-54-0
Molecular Formula	C21H25NO5
Molecular Weight	371.43 g/mol
Synonyms	N-Carbobenzoxy-O-tert-butyl-L-tyrosine; Z-O-tert-butyl-L-tyrosine; N-(Benzyloxycarbonyl)-O-(tert-butyl)-L-tyrosine; Z-L-Tyr(tBu)-OH; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid; Boc-Tyr(tBu)-OH (common misnomer, correct prefix is Z-); CBZ-Tyr(TBU)-OH; Nα-Cbz-O-tert-butyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our Z-Tyr(Tbu)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay, optical rotation, and residual solvent levels. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-10.0° to -12.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0% L-isomer
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.