Description

(R)-(+)-Warfarin CAS NO 5543-58-8 is the pharmacologically active enantiomer of the widely used anticoagulant warfarin. This high-purity chiral compound is essential for advanced pharmaceutical research and development, particularly in studying stereospecific drug metabolism and receptor interactions. It is a critical reference standard and starting material for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require precise enantiomeric control.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for analytical method development, validation, and quality control in drug testing.
• Metabolic and Pharmacokinetic Studies: Key reagent for investigating the stereoselective metabolism, distribution, and activity of warfarin in biological systems.
• Chiral Synthesis & Intermediate: Serves as a high-value chiral building block or intermediate in the synthesis of novel anticoagulant agents or targeted pharmaceuticals.
• Biochemical Research: Used in enzymatic studies, particularly for research on vitamin K epoxide reductase (VKOR) and related coagulation pathways.
• Academic & Institutional Research: Fundamental tool for universities and research institutes conducting studies in medicinal chemistry, pharmacology, and toxicology.

Basic Information

Product Name	(R)-(+)-Warfarin
CAS No.	5543-58-8
Molecular Formula	C19H16O4
Molecular Weight	308.33 g/mol
Synonyms	(R)-(+)-3-(α-Acetonylbenzyl)-4-hydroxycoumarin; (R)-Warfarin; (+)-Warfarin; R-Warfarin; (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one; Dextro-warfarin; Coumadin (R-enantiomer); Warfarin R(+)-enantiomer; 2H-1-Benzopyran-2-one, 4-hydroxy-3-((1R)-3-oxo-1-phenylbutyl)-
EINECS	226-904-3

Quality Control

Our (R)-(+)-Warfarin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing full specifications, including enantiomeric excess (ee), is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.