Description

(S)-(-)-Warfarin CAS NO 5543-57-7 is the single enantiomer of the widely recognized anticoagulant agent, offering a high-purity standard for research and development. This specific stereoisomer is critical for studies investigating the stereoselective metabolism, pharmacokinetics, and receptor binding interactions of warfarin. It is an essential reference standard and key intermediate for pharmaceutical companies, analytical laboratories, and academic institutions focused on cardiovascular research, drug metabolism, and chiral chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, GC-MS) for quality control of racemic warfarin APIs and finished dosage forms.
• Metabolic and Pharmacokinetic Research: Critical for in vitro and in vivo studies to understand the distinct biological activity, clearance rates, and drug-drug interactions of the (S)-enantiomer.
• Chiral Synthesis Intermediate: Serves as a building block for the synthesis of novel anticoagulant compounds or for creating deuterated/internal standards for bioanalytical assays.
• Biochemical Assay Development: Employed in enzyme inhibition studies targeting vitamin K epoxide reductase (VKOR) to screen for new therapeutic agents.
• Academic & Clinical Research: Supports fundamental research in hematology, cardiology, and personalized medicine related to warfarin therapy and genetic polymorphisms (e.g., CYP2C9, VKORC1).

Basic Information

Product Name	(S)-(-)-Warfarin
CAS No.	5543-57-7
Molecular Formula	C19H16O4
Molecular Weight	308.33 g/mol
Synonyms	(S)-Warfarin; (S)-3-(α-Acetonylbenzyl)-4-hydroxycoumarin; Levowarfarin; Warfarin S-(-)-enantiomer; Coumadin (S)-enantiomer; (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (S)-
EINECS	226-881-3

Quality Control

Our (S)-(-)-Warfarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, to ensure identity, potency, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided, confirming compliance with in-house specifications suitable for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S)-enantiomer
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.