Description

α-Acetyldigoxin is a semi-synthetic cardiac glycoside derivative, specifically an acetylated form of digoxin. This compound is valued for its precise pharmacological activity and serves as a critical reference standard and intermediate in pharmaceutical research and development. It is primarily utilized by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors for the development and quality control of cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: Used for the calibration, validation, and quality control (QC) of analytical methods (e.g., HPLC, LC-MS) in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the production of specialized cardiac glycoside medications.
• Biochemical Research: Employed in pharmacological studies to investigate the mechanism of action of digitalis-like compounds on sodium-potassium ATPase pumps.
• Metabolite Studies: Used as a standard in pharmacokinetic and metabolic pathway research related to digoxin and its derivatives.
• Formulation Development: Aids in the development of stable and bioavailable dosage forms for cardiovascular drugs.

Basic Information

Product Name	α-Acetyldigoxin
CAS No.	5511-98-8
Molecular Formula	C₄₃H₆₆O₁₅
Molecular Weight	823.0 g/mol
Synonyms	Acetyldigoxin; α-Acetyldigoxin; 3β-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide 16-acetate; Digoxin 16'-acetate; α-Digoxin acetate
EINECS	226-856-6

Quality Control

Our α-Acetyldigoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.