Description

4-Phenylisovaline is a non-proteinogenic amino acid derivative characterized by its unique isovaline backbone substituted with a phenyl group. This structural motif makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, enzyme inhibitors, and other bioactive compounds. The compound is supplied under stringent quality control to ensure consistency for critical applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Biochemical Research: Used as a standard or reagent in studies of amino acid metabolism, enzyme kinetics, and protein structure-function relationships.
• Peptide Synthesis: Incorporated into custom peptides to modulate their stability, bioavailability, and receptor binding affinity due to its non-natural side chain.
• Asymmetric Catalysis: Employed as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Academic & Industrial R&D: A fundamental compound for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	4-Phenylisovaline
CAS No.	5472-95-7
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	4-Phenyl-2-amino-3-methylbutanoic acid; (2S,3S)-2-Amino-3-methyl-4-phenylbutanoic acid; (S,S)-4-Phenylisovaline; 4-Phenyl-D-isovaline; 2-Amino-3-methyl-4-phenylbutyric acid; 4-Phenyl-3-methyl-DL-alanine; α-Amino-β-methyl-γ-phenylbutyric acid
EINECS	Contact for details

Quality Control

Our 4-Phenylisovaline is manufactured under a quality management system to ensure batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including chiral purity assessment, to meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment. We support compliance with relevant regulatory frameworks for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (specify enantiomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.