Description

2,4-Dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid is a high-purity, heterocyclic carboxylic acid derivative that serves as a critical advanced pharmaceutical intermediate and versatile synthetic building block. Its value lies in its unique fused bicyclic structure, which provides a privileged scaffold for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in high-throughput screening campaigns.
• Agrochemical Development: Used in the research and synthesis of new herbicides, fungicides, and plant growth regulators due to its bioactive quinazoline core.
• Fine Chemical Synthesis: A versatile precursor for creating complex heterocyclic compounds, dyes, and specialty chemicals.
• Academic & Contract Research: Essential material for universities and CROs (Contract Research Organizations) conducting fundamental organic synthesis and method development.
• Process Chemistry Optimization: Used in scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	2,4-Dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic Acid
CAS No.	5458-56-0
Molecular Formula	C9H8Cl2N2O2
Molecular Weight	247.08 g/mol
Synonyms	6-Carboxy-2,4-dichloro-5,6,7,8-tetrahydroquinazoline; 2,4-Dichloro-5,6,7,8-tetrahydro-6-quinazolinecarboxylic Acid; 5,6,7,8-Tetrahydro-2,4-dichloroquinazoline-6-carboxylic Acid; 2,4-Dichlorotetrahydroquinazoline-6-carboxylic Acid; THQ-6-COOH Derivative; A-5458560; 5458-56-0; SCHEMBL2184227
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5,6,7,8-tetrahydroquinazoline-6-carboxylic acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.