Description

α-Methyl-Dl-Serine is a non-proteinogenic amino acid derivative, serving as a crucial chiral building block and intermediate in advanced organic synthesis. Its modified structure, featuring an additional methyl group on the alpha carbon, makes it a valuable synthon for creating novel peptides and bioactive compounds with tailored properties. This compound is primarily utilized by research institutions and pharmaceutical developers in medicinal chemistry, as well as by fine chemical manufacturers producing specialized reagents and ligands.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, peptide mimetics, and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new pharmacophores and modify peptide backbone properties.
• Chiral Auxiliary/Synthon: Serves as a starting material for the preparation of other non-natural amino acids and complex chiral molecules.
• Biochemical Research: Employed in studies of amino acid metabolism, enzyme mechanisms, and as a substrate analog.
• Fine Chemical Synthesis: Intermediate in the production of specialized ligands, catalysts, and advanced materials.

Basic Information

Product Name	α-Methyl-Dl-Serine
CAS No.	5424-29-3
Molecular Formula	C4H9NO3
Molecular Weight	119.12 g/mol
Synonyms	2-Amino-2-methyl-3-hydroxypropanoic acid; DL-2-Amino-2-methylserine; (±)-2-Amino-2-methyl-3-hydroxypropanoic acid; 2-Methylserine; α-Methylserine; AMS; 2-Amino-2-methyl-3-hydroxypropionic acid
EINECS	226-577-5

Quality Control

Our α-Methyl-Dl-Serine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Optical Rotation (c=1 in H2O)	± 0.5° (for racemic mixture)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.