Description

7-Chloro-1,3-Dihydro-5-(2-Methylphenyl)-2H-1,4-Benzodiazepine-2-One is a high-purity benzodiazepine derivative, a critical intermediate in advanced pharmaceutical synthesis. Its value lies in providing a reliable and consistent building block for research and development, ensuring downstream product quality and process stability. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Synthesis: Employed as a specialized building block in complex organic synthesis for introducing the benzodiazepine core structure.

Basic Information

Product Name	7-Chloro-1,3-Dihydro-5-(2-Methylphenyl)-2H-1,4-Benzodiazepine-2-One
CAS No.	5358-35-0
Molecular Formula	C₁₆H₁₃ClN₂O
Molecular Weight	284.74 g/mol
Synonyms	7-Chloro-5-(o-tolyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-methylphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(2-methylphenyl)-; Ro 05-2921; 5358-35-0
EINECS	Contact for details

Quality Control

Our 7-Chloro-1,3-Dihydro-5-(2-Methylphenyl)-2H-1,4-Benzodiazepine-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.