Description

n-[(tert-Butoxy)Carbonyl]-D-Tryptophan is a protected derivative of the essential amino acid D-tryptophan, widely used as a critical chiral building block in peptide synthesis. This compound matters for its role in introducing the D-tryptophan residue while preventing unwanted side reactions during the assembly of complex peptide chains. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-tryptophan moiety with its indole side chain protected.
• Research & Development: Employed in academic and industrial R&D for creating novel peptide libraries and investigating structure-activity relationships (SAR).
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in the asymmetric synthesis of more complex chiral molecules.

Basic Information

Product Name	n-[(tert-Butoxy)Carbonyl]-D-Tryptophan
CAS No.	5241-64-5
Molecular Formula	C₁₆H₂₀N₂O₄
Molecular Weight	304.34 g/mol
Synonyms	Boc-D-Trp-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid; D-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-; Boc-D-Tryptophan; N-Boc-D-tryptophan; N-tert-Butoxycarbonyl-D-tryptophan; (R)-N-Boc-tryptophan; D-Boc-Trp
EINECS	226-037-9

Quality Control

Our n-[(tert-Butoxy)Carbonyl]-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.