Description

H-D-Phe-Nh2 CAS NO 5241-59-8 is a high-purity, non-natural amino acid derivative, specifically the amide of D-phenylalanine. This chiral building block is critical for synthesizing peptides and peptidomimetics with enhanced metabolic stability and specific biological activity. It is an essential raw material for pharmaceutical R&D and production, particularly in developing therapeutic peptides, enzyme inhibitors, and advanced drug delivery systems.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-phenylalanine residues, which can confer resistance to enzymatic degradation.
• Protease Inhibitor Development: Serves as a core component in the design of inhibitors for various proteases (e.g., HIV protease, renin).
• Biochemical Research: Utilized in academic and industrial research to study peptide structure-activity relationships (SAR) and chiral recognition.
• Cosmetic Peptides: Potential ingredient in the synthesis of bioactive peptides for cosmetic applications, such as anti-aging or skin-conditioning agents.
• Agrochemical Synthesis: Intermediate for creating chiral active ingredients in certain pesticides and herbicides.

Basic Information

Product Name	H-D-Phe-Nh2
CAS No.	5241-59-8
Molecular Formula	C9H12N2O
Molecular Weight	164.20 g/mol
Synonyms	D-Phenylalaninamide; (R)-2-Amino-3-phenylpropanamide; D-α-Aminohydrocinnamamide; D-Phe-NH2; H-D-Phe-NH2; D-Phenylalanine amide; (R)-Phenylalaninamide; D-Phenylalanineamide
EINECS	226-049-5

Quality Control

Our H-D-Phe-Nh2 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation	-30° to -34° (c=1 in 1N HCl)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.