Description

2,4-Dichloro-5-Aminopyrimidine CAS NO 5177-27-5 is a versatile halogenated aminopyrimidine building block of significant importance in synthetic organic chemistry. Its core value lies in its bifunctional reactivity, where the chlorine atoms and the amino group serve as distinct handles for sequential nucleophilic substitution and cross-coupling reactions. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic scaffolds. It serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), nucleoside analogs, and various fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of antiviral, anticancer, and kinase inhibitor drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Nucleoside & Nucleotide Chemistry: Serves as a building block for modified nucleosides and related bioactive compounds.
• Material Science: Employed in the research and development of organic electronic materials and ligands for metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to introduce the pyrimidine core.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing diverse heterocyclic libraries.

Basic Information

Product Name	2,4-Dichloro-5-Aminopyrimidine
CAS No.	5177-27-5
Molecular Formula	C4H3Cl2N3
Molecular Weight	163.99 g/mol
Synonyms	5-Amino-2,4-dichloropyrimidine; 2,4-Dichloro-5-pyrimidinamine; 5-Pyrimidinamine, 2,4-dichloro-; 2,4-Dichloropyrimidin-5-amine; NSC 403697; 2,4-Dichloro-5-aminopyrimidine; 2,4-Dichloro-5-pyrimidinamine
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-Aminopyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.