Description

Metocurine is a non-depolarizing neuromuscular blocking agent belonging to the bisbenzylisoquinolinium class of compounds. This compound is of significant interest in pharmacological research and development, particularly for studying neuromuscular junction physiology and as a reference standard. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers engaged in neuroscience, anesthesiology, and comparative pharmacology studies.

Application

• Pharmacological Research: Used as a reference standard and tool compound in studies of neuromuscular transmission and nicotinic acetylcholine receptor function.
• Anesthesia Research: Investigated for its properties as a neuromuscular blocking agent in experimental models.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method development in analytical chemistry (e.g., HPLC, LC-MS).
• Neuroscience Studies: Employed in electrophysiological research to understand the mechanisms of action at the post-synaptic membrane.
• Toxicology & Safety Assessment: Used in comparative studies of muscle relaxants and their side-effect profiles.
• Biochemical Assay Development: Acts as a key reagent in developing in vitro assays for screening potential new therapeutic agents.

Basic Information

Product Name	Metocurine
CAS No.	5152-30-7
Molecular Formula	C40H48N2O6·2I
Molecular Weight	906.64 g/mol
Synonyms	Metocurine Iodide; Dimethyltubocurarine Iodide; (2β,2'β)-2,2'-[1,5-Pentanediylbis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] Diiodide; Mecostrin; Metubine; d-Tubocurarine Dimethyl Ether Iodide
EINECS	225-904-9

Quality Control

Our Metocurine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.