Description

4-Hydroxybenzoylcholine is a choline ester derivative of 4-hydroxybenzoic acid, serving as a valuable biochemical tool and research compound. Its primary significance lies in its role as a selective and potent agonist for the α7 subtype of nicotinic acetylcholine receptors (nAChRs), making it a critical reagent for neurological and pharmacological research. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for studying receptor function, signal transduction pathways, and developing novel therapeutics for cognitive disorders.

Application

• Neurological Research: As a selective α7 nAChR agonist for studying receptor activation, desensitization, and allosteric modulation in vitro and in vivo.
• Drug Discovery & Screening: Used as a reference standard and pharmacological tool in high-throughput screening assays to identify and validate new drug candidates targeting the cholinergic system.
• Biochemical Studies: Employed in investigating cholinergic signaling pathways, calcium influx, and neurotransmitter release mechanisms.
• Cognitive Disorder Research: Applied in models for Alzheimer's disease, schizophrenia, and other cognitive impairments to explore potential therapeutic interventions.
• Acetylcholinesterase (AChE) Studies: Serves as a substrate or inhibitor in enzymatic studies to understand AChE kinetics and inhibition.
• Standards & Calibration: Used as a certified reference material (CRM) or analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.

Basic Information

Product Name	4-Hydroxybenzoylcholine
CAS No.	5094-31-5
Molecular Formula	C12H17NO3
Molecular Weight	223.27 g/mol
Synonyms	p-Hydroxybenzoylcholine; 4-Hydroxybenzoylcholine chloride (common salt form); Choline 4-hydroxybenzoate; (2-Hydroxyethyl)trimethylammonium 4-hydroxybenzoate; N,N,N-Trimethyl-2-[(4-hydroxybenzoyl)oxy]ethanaminium; BACh; α7 nAChR agonist (Selective)
EINECS	Contact for details

Quality Control

Our 4-Hydroxybenzoylcholine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Keep container tightly sealed when not in use to prevent absorption of moisture and CO2.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.