Description

(R)-Phenprocoumon CAS NO 599-27-9 is a high-purity, single-enantiomer anticoagulant compound belonging to the coumarin derivative class. This chiral specificity is critical for research and development in pharmacology, where the distinct biological activity of the (R)-enantiomer is of primary interest. It is an essential reference standard and key intermediate for pharmaceutical scientists, medicinal chemists, and advanced research laboratories focused on cardiovascular drug discovery and metabolic studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quality control and analytical method development of anticoagulant APIs and finished dosage forms.
• Medicinal Chemistry Research: Used as a key chiral building block or intermediate in the synthesis and structure-activity relationship (SAR) studies of novel vitamin K antagonists.
• Biochemical & Pharmacological Studies: Employed in in vitro and in vivo research to investigate the mechanism of action, metabolism, and enantioselective pharmacokinetics of coumarin-based anticoagulants.
• Active Pharmaceutical Ingredient (API) Development: Acts as a starting material or intermediate in the development and scale-up of enantiomerically pure anticoagulant drug candidates.
• Academic & Institutional Research: Utilized in university and institutional labs for advanced studies in hematology, coagulation pathways, and chiral drug metabolism.

Basic Information

Product Name	(R)-Phenprocoumon
CAS No.	599-27-9
Molecular Formula	C₁₈H₁₆O₃
Molecular Weight	280.32 g/mol
Synonyms	(R)-3-(1-Phenylpropyl)-4-hydroxycoumarin; (R)-Marcoumar; (R)-Falithrom; (R)-Liquamar; Phenprocoumon, (R)-isomer; (R)-PPC; 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-one, (R)-
EINECS	Contact for details

Quality Control

Our (R)-Phenprocoumon is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.