Description

L-Isovaline is a non-proteinogenic amino acid with the CAS number 595-40-4, structurally related to the essential branched-chain amino acids. This unique compound is of significant interest in biochemical research and pharmaceutical development due to its role as a selective agonist for certain metabotropic glutamate receptors (mGluRs). It serves as a critical building block and research chemical for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel drug candidates targeting neurological pathways.
• Biochemical Studies: Used as a research tool to study the function and modulation of metabotropic glutamate receptors (Group II mGluRs).
• Peptide Synthesis: Incorporated into custom peptides to alter their structure, stability, and biological activity for therapeutic applications.
• Neuroscience Research: Investigation of its neuroprotective properties and potential role in conditions like epilepsy, anxiety, and neurodegenerative diseases.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Chemical Biology: A probe for understanding amino acid transport and metabolism in biological systems.

Basic Information

Product Name	L-Isovaline
CAS No.	595-40-4
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	(S)-2-Amino-2-methylbutanoic acid; (S)-2-Amino-2-methylbutyric acid; (S)-2-Methyl-2-aminobutanoic acid; L-2-Amino-2-methylbutyric acid; L-α-Aminoisovaleric acid; L-2-Methyl-2-aminobutyric acid; (S)-α-Aminoisovaleric acid
EINECS	209-871-5

Quality Control

Our L-Isovaline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.