Description

α-Methylhistidine is a naturally occurring, non-proteinogenic amino acid derivative of histidine. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a potential biomarker and its involvement in metabolic pathways. It is primarily utilized by research institutions, pharmaceutical companies, and diagnostic manufacturers for applications in metabolic studies, analytical reference standards, and the development of nutritional supplements.

Application

• Biochemical Research: Used as a key intermediate or reference standard in studies of histidine metabolism, muscle metabolism, and carnosine synthesis.
• Pharmaceutical Development: Serves as a starting material or intermediate in the synthesis of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Diagnostic Reagents: Employed in the formulation of calibration standards and reagents for clinical diagnostic kits, particularly those analyzing muscle-related biomarkers.
• Nutritional Science: Investigated for its potential role and benefits as a component in advanced sports nutrition and dietary supplements.
• Analytical Chemistry: Acts as a high-purity standard for method development and validation in HPLC, LC-MS, and other chromatographic analyses.

Basic Information

Product Name	α-Methylhistidine
CAS No.	587-20-2
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	1-Methyl-L-histidine; L-1-Methylhistidine; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid; Hercynine; Thioneine; 1-Methylhistidine; 1-N-Methylhistidine; 1-MeHis
EINECS	209-607-5

Quality Control

Our α-Methylhistidine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (typically ≥98% by HPLC), and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.