Description

3-Hydroxyproline is a non-proteinogenic amino acid derivative of proline, characterized by the addition of a hydroxyl group at the 3-position of the pyrrolidine ring. This specific structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is particularly sought after by research institutions and manufacturers in the life sciences sector for developing novel therapeutic agents and biochemical tools. The compound is supplied to meet the stringent quality requirements of these demanding applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting collagen-related disorders or requiring specific stereochemistry.
• Biochemical Research: Used as a standard or reagent in metabolic pathway studies, enzyme-substrate interaction research, and investigations into collagen biosynthesis and stability.
• Peptide Synthesis: Incorporated into custom peptides to study the effects of hydroxylation on peptide structure, stability, and biological activity.
• Cosmetic & Dermatological R&D: Investigated for its potential role in formulations aimed at skin repair and anti-aging, due to its relationship to collagen structure.
• Academic & Industrial R&D: Serves as a fundamental building block in medicinal chemistry programs for creating new chemical entities (NCEs).

Basic Information

Product Name	3-Hydroxyproline
CAS No.	567-36-2
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid; (2S,3R)-3-Hydroxyproline; cis-3-Hydroxyproline; 3(R)-Hydroxy-L-proline; 3-Hydroxy-L-proline; L-3-Hydroxyproline; 3-Hyp; Hydroxyproline
EINECS	209-296-6

Quality Control

Our 3-Hydroxyproline is produced and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity determination by HPLC, and specific tests for optical rotation and related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-70° to -76° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.