Description

(2S,3R)-3-Hydroxyproline is a non-proteinogenic, stereospecific hydroxyproline isomer, a key building block in organic synthesis and peptide research. This compound is valued for its role in modulating peptide conformation and stability, which is critical for developing bioactive molecules. It is primarily utilized by pharmaceutical researchers, peptide chemists, and fine chemical manufacturers working on collagen mimetics, therapeutic peptides, and advanced drug discovery programs.

Application

• Pharmaceutical Intermediates: A critical chiral synthon for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Synthesis & Research: Used to incorporate specific conformational constraints into synthetic peptides, enhancing their biological activity and metabolic stability.
• Collagen Model Peptides: Essential for constructing peptides that mimic the structure and function of collagen, aiding in biomaterials and tissue engineering research.
• Biochemical Research: Serves as a standard or reagent in studies of collagen biosynthesis, post-translational modification, and enzyme-substrate interactions.
• Fine Chemical Synthesis: Employed as a versatile chiral building block in asymmetric synthesis for complex natural products and specialty chemicals.

Basic Information

Product Name	(2S,3R)-3-Hydroxyproline
CAS No.	567-35-1
Molecular Formula	C5H9NO3
Molecular Weight	131.13 g/mol
Synonyms	(2S,3R)-3-Hydroxypyrrolidine-2-carboxylic acid; (3R)-3-Hydroxy-L-proline; allo-3-Hydroxy-L-proline; (2S,3R)-3-Hydroxyproline; L-allo-3-Hydroxyproline; 3(R)-Hydroxy-L-proline; (2S,3R)-3-Hydroxypyrrolidine-2-carboxylic Acid; allo-Hyp
EINECS	209-296-6

Quality Control

Our (2S,3R)-3-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2S,3R)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.