Description

Netropsin is a naturally occurring, non-intercalating, minor groove-binding oligopeptide antibiotic with potent antiviral and antibacterial properties. Its high-affinity binding to specific AT-rich sequences of double-stranded DNA makes it a crucial tool in molecular biology and biochemical research. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for studying DNA-protein interactions, nucleic acid structure, and as a lead compound for therapeutic development.

Application

• Molecular Biology Research: Used as a specific probe to study DNA conformation, protein-DNA interactions, and the mechanism of gene regulation.
• Biochemical Studies: Employed in footprinting assays to identify protein binding sites on DNA due to its sequence-specific binding.
• Antiviral Agent Development: Serves as a lead compound in research for developing agents against viruses like herpes simplex and human papillomavirus (HPV).
• Antibacterial Research: Investigated for its activity against Gram-positive bacteria, providing a model for novel antibiotic design.
• Cancer Research: Studied for its potential to interfere with DNA replication in rapidly dividing cells, offering insights into chemotherapeutic strategies.
• Diagnostic Reagent Formulation: Can be utilized in the development of diagnostic kits that rely on specific nucleic acid recognition.

Basic Information

Product Name	Netropsin
CAS No.	554-32-5
Molecular Formula	C₁₈H₂₆N₁₀O₄
Molecular Weight	446.47 g/mol
Synonyms	Netropsin; Congocidine; Sinanomycin; Antibiotic 5-113; NSC 57153; 2-[[4-[[(2-Amino-1-methyl-4,5-dihydro-1H-imidazol-5-yl)methylamino]methyl]pyrimidin-2-yl]amino]-N-(3-aminopropyl)acetamide; 1-Methyl-2-[4-[[(1-methyl-2-imidazolin-2-yl)amino]methyl]pyrimidin-2-yl]guanidine
EINECS	209-064-9

Quality Control

Our Netropsin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopy for identification, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (Assay)	Confirmed

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.