Description

Sennosides CAS NO 517-43-1 is a purified mixture of anthraquinone glycosides, primarily Sennoside A and B, derived from the senna plant. This active pharmaceutical ingredient (API) is valued for its reliable and predictable stimulant laxative effect, making it a cornerstone in the formulation of over-the-counter and prescription constipation relief medications. It is essential for pharmaceutical manufacturers, nutraceutical producers, and research institutions developing gastrointestinal therapeutics and standardized botanical extracts.

Application

• Pharmaceutical API: Primary active ingredient in stimulant laxative tablets, capsules, and oral solutions.
• OTC Drug Formulations: Key component in widely available constipation relief and bowel preparation products.
• Herbal & Nutraceutical Extracts: Standardized extract used in dietary supplements for natural digestive support.
• Veterinary Pharmaceuticals: Used in laxative preparations for animal healthcare.
• Clinical Research: Reference standard and investigational material for studying gastrointestinal motility and pharmacology.
• Bulk Drug Substance: Sourced by contract manufacturing organizations (CMOs) for secondary manufacturing and packaging.

Basic Information

Product Name	Sennosides
CAS No.	517-43-1
Molecular Formula	C42H38O20 (for Sennoside A)
Molecular Weight	862.75 g/mol (for Sennoside A)
Synonyms	Sennoside; Sennosides A and B; Senna Extract; Glycosides of Senna; Rhein-8-glucoside dimer; Cassia glycoside; 5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid dimethyl ester
EINECS	208-239-7

Quality Control

Our Sennosides is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, purity, potency, and related substances via validated methods such as HPLC. A detailed Certificate of Analysis (COA) is provided, confirming compliance with specifications for pharmaceutical use. Our quality system adheres to cGMP principles to ensure supply chain reliability and product consistency for global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	Fine, light yellow to brownish-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (Total Sennosides, HPLC)	NLT 90.0% (calculated as Sennoside B)
Sennoside A (HPLC)	Report result on COA
Sennoside B (HPLC)	Report result on COA
Loss on Drying	NMT 8.0%
Residue on Ignition	NMT 1.0%
Heavy Metals	NMT 20 ppm
Microbial Limits	Meets USP <61> and <62> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.