Description

Tetrabenazine is a high-purity pharmaceutical active ingredient and vesicular monoamine transporter 2 (VMAT2) inhibitor. Its primary value lies in its critical role as the active pharmaceutical ingredient (API) in treatments for hyperkinetic movement disorders, such as Huntington's disease and tardive dyskinesia. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics. We supply Tetrabenazine CAS NO 58-46-8 to the global market, ensuring consistent quality and reliable supply for your most demanding applications.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for chorea associated with Huntington's disease.
• Neurological Research: Critical compound for preclinical and clinical studies targeting monoamine depletion and movement disorders.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded VMAT2 inhibitor therapeutics.
• Dosage Form Development: Used in the formulation of tablets and other solid oral dosage forms.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in laboratories.
• Biochemical Pathway Studies: Tool for investigating the vesicular monoamine transport system and its role in neurotransmission.

Basic Information

Product Name	Tetrabenazine
CAS No.	58-46-8
Molecular Formula	C19H27NO3
Molecular Weight	317.42 g/mol
Synonyms	Nitoman; Ro 1-9569; TBZ; 1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; Benzquinamide; Xenazine
EINECS	200-381-9

Quality Control

Our Tetrabenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF Titration)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.