Description

Prochlorperazine CAS NO 58-38-8 is a high-purity phenothiazine derivative belonging to the piperazine class, widely recognized for its potent dopaminergic antagonist activity. This compound is a critical active pharmaceutical ingredient (API) essential for the formulation of antiemetic and antipsychotic medications. It is primarily required by pharmaceutical manufacturers, research institutions, and chemical distributors serving the global healthcare sector for the development and production of reliable therapeutic solutions.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for severe nausea, vomiting, and vertigo.
• Antipsychotic Formulations: Used in the manufacture of drugs for the management of schizophrenia and other psychotic disorders.
• Antiemetic Injections: Key component in injectable solutions for postoperative and chemotherapy-induced nausea and vomiting.
• Oral Dosage Forms: Incorporated into tablets, capsules, and syrups for controlled oral delivery.
• Neurological Research: Serves as a reference standard and tool compound in neuropharmacology and receptor binding studies.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for the control of emesis in animals.
• Chemical Intermediate: Utilized in synthetic organic chemistry for the development of novel phenothiazine analogs.
• Reference Standard: Supplied as a certified reference material (CRM) for quality control and analytical testing in laboratories.

Basic Information

Product Name	Prochlorperazine
CAS No.	58-38-8
Molecular Formula	C₂₀H₂₄ClN₃S
Molecular Weight	373.94 g/mol
Synonyms	Prochlorperazine; 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; Compazine; Stemetil; Novamin; Chlorperazine; Prorazin; Tementil; Vertigon; Buccastem; 58-38-8
EINECS	200-379-7

Quality Control

Our Prochlorperazine is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and other pharmacopeial methods. We ensure compliance with relevant standards such as USP/EP monographs. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and specification conformance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to pale yellow, crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.