Description

Tubocurarine CAS NO 57-95-4 is a bisbenzylisoquinoline alkaloid and a potent, non-depolarizing neuromuscular blocking agent. It is a critical compound in pharmacological research and development, primarily known for its role as a skeletal muscle relaxant. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly for studies in anesthesia, neuropharmacology, and the development of therapeutic agents.

Application

• Pharmacological Research: A key reference standard and tool compound for studying neuromuscular transmission, nicotinic acetylcholine receptors, and the mechanisms of non-depolarizing muscle relaxants.
• Anesthesia & Surgical Adjunct Studies: Used in preclinical research to investigate the effects and pharmacokinetics of muscle relaxation during surgical procedures.
• Neuroscience & Neurobiology: Employed in electrophysiological studies to block nicotinic receptors at the neuromuscular junction and autonomic ganglia.
• Pharmaceutical Development: Serves as a lead compound or comparator in the development of new neuromuscular blocking agents or reversal drugs.
• Toxicology & Safety Assessment: Utilized in studies to understand the toxicological profile of curare-type compounds and to establish safety margins.
• Academic & Educational Use: A standard teaching tool in university laboratories for demonstrating the principles of competitive antagonism at cholinergic receptors.

Basic Information

Product Name	Tubocurarine
CAS No.	57-95-4
Molecular Formula	C37H41N2O6+
Molecular Weight	609.74 g/mol (as chloride salt)
Synonyms	d-Tubocurarine; Tubocurarine Chloride; (+)-Tubocurarine Chloride; Amelizol; Curarin; Delacurarine; Intocostrin; Tubarine; Tubadil; (R)-Tubocurarine; 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2-ium
EINECS	200-390-1

Quality Control

Our Tubocurarine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing specific results for parameters such as HPLC purity, water content, and residue on ignition are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	+190° to +210° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.