Description

D-Tubocurarine Chloride is a potent, non-depolarizing neuromuscular blocking agent derived from the plant *Chondrodendron tomentosum*. This compound is a critical reference standard and active pharmaceutical ingredient (API) in pharmacological research and development. It is primarily utilized by pharmaceutical manufacturers, research institutions, and analytical laboratories for studying neuromuscular junction physiology, calibrating bioassays, and developing anesthetic protocols.

Application

• Pharmacological Research: As a classic nicotinic acetylcholine receptor antagonist for studying neuromuscular transmission and autonomic ganglia.
• Reference Standard: For the quality control and analytical method validation of neuromuscular blocking agents in pharmaceutical development.
• Physiological Studies: In experimental models to investigate skeletal muscle relaxation and the mechanisms of action of curare alkaloids.
• Anesthesia Adjunct Development: Serves as a key comparator in the R&D of modern muscle relaxants with improved safety profiles.
• Biochemical Reagent: Used in receptor binding assays and other in vitro studies targeting the nicotinic acetylcholine receptor.
• Toxicology: Employed in studies related to plant-derived toxins and the treatment of poisoning.

Basic Information

Product Name	D-Tubocurarine Chloride
CAS No.	57-94-3
Molecular Formula	C37H41ClN2O6 • HCl • 5H2O
Molecular Weight	771.73 g/mol (Pentahydrate)
Synonyms	(+)-Tubocurarine Chloride; Tubocurarine Chloride; d-Tubocurarine Chloride Pentahydrate; Tubocurarinii Chloridum; Delacurarine; Intocostrin; Amelizol; Curarin
EINECS	200-359-5

Quality Control

Our D-Tubocurarine Chloride is produced and tested under strict quality management systems to ensure it meets the exacting standards required for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial standards (e.g., USP, EP) upon request, ensuring traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to pale yellow, crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	10.0% - 13.0% (Pentahydrate)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	+210° to +225° (c = 1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.