Description

Angiotensin II, Asp(1)-Val(5)- is a specific, biologically active fragment of the angiotensin II peptide hormone. This compound is of significant value in biochemical and pharmacological research for studying the renin-angiotensin system (RAS), which is critical in regulating blood pressure and fluid balance. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers for use as a reference standard, in receptor binding assays, and for the development of cardiovascular therapeutics.

Application

• Biochemical Research: Used as a high-purity reference standard in studies of the renin-angiotensin system (RAS) and its physiological effects.
• Pharmacological Studies: Essential for receptor binding assays and functional studies to evaluate angiotensin II receptor (AT1 & AT2) activity and antagonist screening.
• Pharmaceutical Development: Serves as a key intermediate or reference material in the research and development of cardiovascular drugs targeting hypertension and heart failure.
• Diagnostic Manufacturing: Utilized in the production of immunoassay kits (e.g., ELISA) for the quantitative measurement of related peptides or antibodies in clinical samples.
• Cell Signaling Research: Applied in in vitro cell culture studies to investigate cellular responses, such as vasoconstriction, aldosterone secretion, and cell proliferation pathways.

Basic Information

Item	Details
Product Name	Angiotensin II, Asp(1)-Val(5)-
CAS No.	53-75-8
Molecular Formula	C₄₆H₆₅N₁₁O₁₂
Molecular Weight	948.1 g/mol
Synonyms	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe; [Asp¹, Val⁵]-Angiotensin II; Angiotensin II (1-8) heptapeptide; DRVYIHPF; H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH; Val⁵-Angiotensin II; Hypertension II fragment; Angiotensin II human
EINECS	Contact for details

Quality Control

Our Angiotensin II, Asp(1)-Val(5)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the exacting standards of the pharmaceutical and life science industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.