Description

Glycine, [2-14C] CAS NO 52-64-2 is a carbon-14 labeled isotopologue of the fundamental amino acid glycine, specifically labeled at the 2-carbon position. This product is essential for advanced research requiring precise metabolic pathway tracing and pharmacokinetic studies due to its incorporation into proteins and other biomolecules. It is a critical reagent for scientists in pharmaceutical development, biochemistry, and metabolic research who require high-specific-activity radiolabeled compounds for autoradiography, LC-MS, and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of glycine-based compounds and peptides in preclinical research.
• Biochemical Pathway Analysis: Enables the tracing of glycine's role in central metabolic processes, including the synthesis of proteins, purines, creatine, and glutathione.
• Proteomics and Protein Turnover Research: Incorporated into newly synthesized proteins to measure synthesis rates, degradation, and protein dynamics in cell culture and animal models.
• Medical and Diagnostic Research: Serves as a tool in researching glycine-related disorders and its neuroprotective or metabolic functions.
• Environmental Fate Studies: Applied in research to track the environmental biodegradation and transformation of glycine and related compounds.
• Standards for Analytical Chemistry: Used as an internal standard or reference material in Liquid Chromatography-Mass Spectrometry (LC-MS) and other analytical techniques for quantitative analysis.

Basic Information

Product Name	Glycine, [2-14C]
CAS No.	52-64-2
Molecular Formula	C14CH5NO2 (C*H5NO2)
Molecular Weight	~76.05 g/mol (exact mass depends on specific activity)
Synonyms	[2-14C]Glycine; Glycine-2-14C; Aminoacetic-2-14C acid; 2-14C-Gly; (2-14C)Glycine; NSC 20268; Glycine (carbon-14 labeled); Aminoethanoic-2-14C acid
EINECS	200-272-2

Quality Control

Every batch of Glycine, [2-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Comprehensive testing includes radiochemical purity by HPLC, specific activity determination, and chemical purity analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radiolabeled compounds. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.