Description

Cycloleucine CAS NO 52-52-8 is a synthetic, non-proteinogenic amino acid analog characterized by its unique cyclopropyl ring structure. This compound serves as a critical biochemical tool and pharmaceutical intermediate, primarily valued for its potent and specific inhibitory action against S-adenosylmethionine (SAM) synthetase. It is essential for researchers in life sciences and manufacturers in the pharmaceutical sector requiring a high-purity, reliable compound for metabolic pathway studies and advanced synthesis.

Application

• Biochemical Research: Used as a selective inhibitor of methionine adenosyltransferase (MAT) to study methylation processes, polyamine synthesis, and sulfur amino acid metabolism in cell culture and animal models.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel therapeutic agents targeting metabolic disorders and specific enzyme pathways.
• Metabolic Studies: A vital tool in oncology and neurology research to investigate the role of SAM-dependent methylation in cancer cell proliferation and neurological function.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Enzyme Inhibition Assays: Utilized in high-throughput screening (HTS) to identify and characterize new drugs that interact with the MAT enzyme family.

Basic Information

Product Name	Cycloleucine
CAS No.	52-52-8
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	1-Aminocyclopentanecarboxylic Acid; 1-Amino-1-cyclopentanecarboxylic Acid; Cycloleucin; NSC 1026; (Aminocyclopentyl)carboxylic Acid; ACC; Cycloleucine (USAN); cis-1-Amino-1-cyclopentanecarboxylic Acid
EINECS	200-145-1

Quality Control

Our Cycloleucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets exacting standards for research and pharmaceutical use. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific rotation provided on COA
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.