Description

4-(3-Bromophenyl)-2-Chloropyrimidine is a high-purity halogenated pyrimidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its bifunctional reactivity, offering distinct sites for cross-coupling and nucleophilic substitution reactions, enabling the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Employed as a molecular probe or a scaffold for constructing compound libraries in drug discovery programs.
• Cross-Coupling Reactions: The bromine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Nucleophilic Aromatic Substitution: The 2-chloro position is reactive towards various nucleophiles, allowing for further functionalization of the pyrimidine ring.

Basic Information

Product Name	4-(3-Bromophenyl)-2-Chloropyrimidine
CAS No.	499195-47-0
Molecular Formula	C10H6BrClN2
Molecular Weight	269.53 g/mol
Synonyms	2-Chloro-4-(3-bromophenyl)pyrimidine; 4-(3-Bromophenyl)-2-chloropyrimidine; 3-Bromo-4-(2-chloropyrimidin-4-yl)benzene; 2-Chloro-4-(m-bromophenyl)pyrimidine; 4-(m-Bromophenyl)-2-chloropyrimidine; 2-Chloro-4-(3'-bromophenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(3-Bromophenyl)-2-Chloropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee it meets your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.