Description

Z-Ile-Glu-Thr-Asp-Pna is a specialized peptide substrate designed for biochemical research and diagnostic applications. This compound is critical for studying protease activity, particularly in the context of apoptosis and cellular signaling pathways. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic kit manufacturers requiring high-purity, reliable substrates for enzymatic assays.

Application

• Caspase Activity Assays: Used as a selective colorimetric substrate for measuring caspase-3 and caspase-7 activity in apoptosis research.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors.
• Biochemical Research: Serves as a key reagent for kinetic studies and enzyme characterization in academic and industrial laboratories.
• Diagnostic Development: Integrated into the development of in-vitro diagnostic (IVD) tests for conditions involving dysregulated apoptosis.
• Cell Biology Studies: Applied in cell-based assays to monitor protease activation and function in various disease models.

Basic Information

Product Name	Z-Ile-Glu-Thr-Asp-Pna
CAS No.	498555-58-1
Molecular Formula	C34H44N6O12
Molecular Weight	728.75 g/mol
Synonyms	Z-IETD-pNA; Ac-Ile-Glu-Thr-Asp-p-nitroanilide (Z-blocked); Benzyloxycarbonyl-Ile-Glu-Thr-Asp-p-nitroanilide; Caspase-8 Substrate, Colorimetric; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-pNA; Ac-IETD-pNA; Caspase-8 Inhibitor Substrate; ICE-LAP6 Substrate
EINECS	Contact for details

Quality Control

Our Z-Ile-Glu-Thr-Asp-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by mass spectrometry. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with research-grade specifications and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.