Description

2-Hydroxy-3-(Trifluoromethoxy)Benzaldehyde is a versatile and high-value aromatic aldehyde building block, distinguished by its trifluoromethoxy and phenolic hydroxyl substituents. This compound is essential for the synthesis of complex molecules where the introduction of fluorine-containing groups is required to modulate biological activity, lipophilicity, and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by fine chemical manufacturers producing advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Studies: A valuable substrate for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated aromatics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	2-Hydroxy-3-(Trifluoromethoxy)Benzaldehyde
CAS No.	497959-31-6
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	3-(Trifluoromethoxy)salicylaldehyde; 2-Hydroxy-3-(trifluoromethoxy)benzaldehyde; Salicylaldehyde, 3-(trifluoromethoxy)-; 2-Formyl-6-(trifluoromethoxy)phenol; 3-Trifluoromethoxysalicylaldehyde; Benzaldehyde, 2-hydroxy-3-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-3-(Trifluoromethoxy)Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment. Our quality commitment supports applications from early-stage research to regulated pre-clinical and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.