Description

(D-Lys16)-Acth (1-24) (Human, Bovine, Mouse, Ovine, Porcine, Rabbit, Rat) CAS NO 494750-52-6 is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH) featuring a D-amino acid substitution at position 16. This modification is designed to enhance its metabolic stability and receptor binding affinity for research applications. It serves as a critical biochemical tool for studying the hypothalamic-pituitary-adrenal (HPA) axis, melanocortin receptor signaling, and related endocrine pathways. This high-purity peptide is essential for pharmaceutical R&D, academic research, and diagnostic assay development across multiple species models.

Application

• Biomedical Research: Fundamental studies on ACTH receptor (MC2R) activation, signal transduction, and steroidogenesis.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening programs for metabolic, anti-inflammatory, and skin disorder therapeutics.
• Endocrinology Assays: Critical component in the development and validation of immunoassays (ELISA, RIA) for measuring ACTH levels.
• Neuroscience Studies: Investigation of the peptide's role in stress response, behavior, and neuroendocrine feedback mechanisms.
• Comparative Physiology: Enables cross-species research (Human, Bovine, Mouse, etc.) to understand evolutionary differences in the HPA axis.
• Quality Control: Serves as an analytical reference standard for peptide manufacturers and regulatory testing laboratories.

Basic Information

Product Name	(D-Lys16)-Acth (1-24) (Human, Bovine, Mouse, Ovine, Porcine, Rabbit, Rat)
CAS No.	494750-52-6
Molecular Formula	C₁₄₆H₂₃₈N₄₄O₄₇S
Molecular Weight	3355.8 g/mol
Synonyms	D-Lys16-ACTH (1-24); [D-Lys16]-ACTH (1-24); Adrenocorticotropic Hormone (1-24), D-Lys16-; Corticotropin (1-24) fragment, D-Lys16-; ACTH (1-24) amide, [D-Lys16]-; Cosyntropin derivative; Tetracosactide derivative; Synacthen fragment analogue
EINECS	Contact for details

Quality Control

Our (D-Lys16)-ACTH (1-24) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure high purity and structural integrity, with specifications typically meeting or exceeding 95% purity by HPLC. Certificates of Analysis (COA) are provided, detailing results for assay, related substances, peptide content, and identity confirmation. We support research and development requiring consistent, reliable, and well-documented peptide standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.