Description

3-Chloro-5-Fluorobenzyl Bromide is a versatile and highly reactive halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of halogen atoms, which enables selective functionalization for constructing complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing benzyl-protected amines or heterocyclic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the creation of monomers or functionalized polymers with specific electronic or surface properties.
• Chemical Biology Probes: Useful for the alkylation of biomolecules or the synthesis of tagged compounds for biochemical and diagnostic research.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.

Basic Information

Product Name	3-Chloro-5-Fluorobenzyl Bromide
CAS No.	493024-39-8
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-3-chloro-5-fluorobenzene; (3-Chloro-5-fluorophenyl)methyl Bromide; α-Bromo-3-chloro-5-fluorotoluene; 3-Chloro-5-fluoro(bromomethyl)benzene; 3-Chloro-5-fluorobenzylbromide; 3-Chloro-5-fluoro-α-bromotoluene; Benzene, 1-(bromomethyl)-3-chloro-5-fluoro-
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.