Description

2-(Trifluoroacetyl)-4-(Trifluoromethyl)Aniline, also known as 1-[2-Amino-5-(Trifluoromethyl)Phenyl]-2,2,2-Trifluoroethan-1-One or 4-Amino-3-(Trifluoroacetyl)Benzotrifluoride, is a high-value, multi-fluorinated aromatic amine building block. This compound is critical for introducing the trifluoromethyl and trifluoroacetyl pharmacophores, which are essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

This specialized fluorinated aniline derivative serves as a versatile synthon in advanced organic synthesis. Its primary applications include:

• Pharmaceutical Intermediates: Key building block for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursors: Employed in the synthesis of advanced materials, such as liquid crystals and organic semiconductors, where fluorine substitution tunes electronic properties.
• Complex Ligand Synthesis: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable compound for methodological studies in fluorination reactions and the exploration of new fluorinated compound libraries.

Basic Information

Product Name	2-(Trifluoroacetyl)-4-(Trifluoromethyl)Aniline
CAS No.	489429-73-4
Molecular Formula	C9H5F6NO
Molecular Weight	257.14 g/mol
Synonyms	1-[2-Amino-5-(Trifluoromethyl)Phenyl]-2,2,2-Trifluoroethan-1-One; 4-Amino-3-(Trifluoroacetyl)Benzotrifluoride; 2-Amino-α,α,α,α',α',α'-Hexafluoro-p-toluophenone; 2-Amino-5-(trifluoromethyl)phenyl trifluoromethyl ketone; 4-(Trifluoromethyl)-2-(trifluoroacetyl)aniline; 5-(Trifluoromethyl)-2-(trifluoroacetyl)aniline; 2-(Trifluoroacetyl)-4-(trifluoromethyl)benzenamine
EINECS	Contact for details

Quality Control

Our 2-(Trifluoroacetyl)-4-(Trifluoromethyl)Aniline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality systems are designed to support cGMP and ISO standards for reliable use in regulated research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.