Description

n-[(1,3-Dimethyl-1H-Pyrazol-4-Yl)Methyl]-n-Methyl-5-Phenyl-7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-2-Carboxamide CAS NO 489410-37-9 is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. Its molecular architecture, featuring a trifluoromethyl group and a complex fused ring system, makes it a critical building block for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily targeted at pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing next-generation therapeutics, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of target molecules for drug discovery programs.
• Kinase Inhibitor Research: Used in the development of potential kinase inhibitors due to the pyrazolopyrimidine core's affinity for ATP-binding sites.
• API Development: Employed in the route scouting and process chemistry for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Acts as a scaffold for creating molecular probes to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate for developing new agrochemicals, leveraging the biological activity of fluorinated heterocycles.
• Material Science: Investigated for use in organic electronic materials due to its conjugated system and fluorine content.

Basic Information

Product Name	n-[(1,3-Dimethyl-1H-Pyrazol-4-Yl)Methyl]-n-Methyl-5-Phenyl-7-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidine-2-Carboxamide
CAS No.	489410-37-9
Molecular Formula	C22H21F3N6O
Molecular Weight	442.44 g/mol
Synonyms	5-Phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide, N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-methyl-; N-[(1,3-Dimethyl-1H-pyrazol-4-yl)methyl]-N-methyl-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide; 489410-37-9; UNII-8V2F1S4K0F; 8V2F1S4K0F; Pyrazolo[1,5-a]pyrimidine-2-carboxamide derivative; BDBM50191053; SCHEMBL21802127
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems (ISO 9001) to ensure batch-to-batch consistency and purity. Each lot undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to verify identity and quantify impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, residual solvents, and other critical parameters. We support our partners with full traceability and data packages suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.