Description

2-Chloro-4-(2-Naphthyl)Pyrimidine is a high-purity, functionalized pyrimidine derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of novel pharmaceutical intermediates and agrochemicals. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators due to its bioactive pyrimidine core.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution for introducing the naphthyl-pyrimidine scaffold.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for metal catalysis and organocatalysts.
• Life Science Research: Employed as a biochemical tool compound for probing biological pathways and enzyme functions in academic and industrial research settings.

Basic Information

Product Name	2-Chloro-4-(2-Naphthyl)Pyrimidine
CAS No.	488816-96-2
Molecular Formula	C₁₄H₉ClN₂
Molecular Weight	240.69 g/mol
Synonyms	4-(Naphthalen-2-yl)-2-chloropyrimidine; 2-Chloro-4-(naphthalen-2-yl)pyrimidine; 2-Chloro-4-naphthalen-2-yl-pyrimidine; 2-Chloro-4-(2-naphthyl)pyrimidine; 488816-96-2; 4-(2-Naphthyl)-2-chloropyrimidine; Pyrimidine, 2-chloro-4-(2-naphthyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(2-Naphthyl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.