Description

Isopropyl 4-[2-(2-Methoxyphenyl)Vinyl]-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders or possessing specific receptor-binding profiles.
• Organic Synthesis Building Block: Utilized in research-scale and pilot-scale organic reactions to construct dihydropyrimidine and related heterocyclic cores, which are privileged structures in medicinal chemistry.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development, quality control, and regulatory submissions in pharmaceutical analysis.
• Academic & Contract Research: Used in university laboratories and contract research organizations (CROs) for exploring new synthetic pathways and studying structure-activity relationships (SAR).
• Process Chemistry Development: Integral to scaling up synthetic routes from laboratory to pilot plant, aiding in the optimization of yield, purity, and cost-effectiveness for potential commercial APIs.

Basic Information

Product Name	Isopropyl 4-[2-(2-Methoxyphenyl)Vinyl]-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	488812-61-9
Molecular Formula	C18H21NO4
Molecular Weight	315.37 g/mol
Synonyms	Isopropyl 4-[(E)-2-(2-Methoxyphenyl)ethenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carboxyisopropyl 4-(2-(2-methoxyphenyl)vinyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 4-[2-(2-methoxyphenyl)ethenyl]-6-methyl-2-oxo-, 1-methylethyl ester; 4-(2-(2-Methoxyphenyl)vinyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid isopropyl ester; Dihydropyrimidine derivative intermediate; CAS 488812-61-9
EINECS	Contact for details

Quality Control

Our Isopropyl 4-[2-(2-Methoxyphenyl)Vinyl]-6-Methyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.