Description

Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Tosylpyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex pyrimidine core structure. This compound is of critical importance for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, custom synthesis organizations, and pharmaceutical manufacturers engaged in the development of novel drug candidates and fine chemical production.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug molecules, especially those targeting specific enzyme pathways.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for constructing the core scaffold of potential new APIs in various therapeutic classes.
• Chemical Synthesis Research: Employed in academic and industrial R&D labs for studying novel organic reactions and constructing complex heterocyclic libraries.
• Custom Manufacturing: A key material for contract manufacturing organizations (CMOs) producing specialized fine chemicals for client-specific projects.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for the efficient production of target molecules.

Basic Information

Product Name	Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Tosylpyrimidine-5-Carboxylate
CAS No.	488798-40-9
Molecular Formula	C22H21FN2O4S
Molecular Weight	428.48 g/mol
Synonyms	Methyl 4-(4-fluorophenyl)-6-(1-methylethyl)-2-[(4-methylphenyl)sulfonyl]-5-pyrimidinecarboxylate; 5-Pyrimidinecarboxylic acid, 4-(4-fluorophenyl)-6-(1-methylethyl)-2-[(4-methylphenyl)sulfonyl]-, methyl ester; 2-Tosyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-5-carboxylic acid methyl ester; Methyl 4-(p-fluorophenyl)-6-isopropyl-2-(p-tolylsulfonyl)pyrimidine-5-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Tosylpyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.