Description

5-Pyrimidinecarboxylic Acid, 4-(4-Fluorophenyl)-1,2-Dihydro-6-(1-Methylethyl)-2-Oxo-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where precise chemical structure and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of proprietary drug molecules, especially in oncology and central nervous system (CNS) therapeutic research.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating new APIs with potential kinase inhibitory or other targeted activities.
• Chemical Synthesis & Process Chemistry: Employed in laboratory-scale and pilot-scale reactions to explore novel synthetic pathways and optimize manufacturing processes.
• Biochemical Research: Acts as a reference standard or a tool compound in biochemical assays to study enzyme interactions and cellular pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	5-Pyrimidinecarboxylic Acid, 4-(4-Fluorophenyl)-1,2-Dihydro-6-(1-Methylethyl)-2-Oxo-, Methyl Ester
CAS No.	488798-37-4
Molecular Formula	C15H15FN2O3
Molecular Weight	290.29 g/mol
Synonyms	Methyl 4-(4-fluorophenyl)-1,2-dihydro-6-isopropyl-2-oxopyrimidine-5-carboxylate; 4-(4-Fluorophenyl)-6-isopropyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid methyl ester; 6-Isopropyl-4-(4-fluorophenyl)-2-oxo-1,2-dihydro-5-pyrimidinecarboxylic acid methyl ester; 488798-37-4; 5-Pyrimidinecarboxylic acid, 4-(4-fluorophenyl)-1,2-dihydro-6-(1-methylethyl)-2-oxo-, methyl ester; 4-(p-Fluorophenyl)-6-isopropyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under quality systems appropriate for your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.