Description

Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and central nervous system disorders. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel dihydropyrimidinone-based therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of calcium channel blockers and other dihydropyrimidinone-class APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up and commercial API production.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and multicomponent reactions like the Biginelli reaction.
• Process Development: Utilized in developing and optimizing robust, scalable synthetic routes for target molecules.

Basic Information

Product Name	Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	488798-36-3
Molecular Formula	C15H17FN2O3
Molecular Weight	292.31 g/mol
Synonyms	Methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbomethoxy-4-(4-fluorophenyl)-6-isopropyl-3,4-dihydropyrimidin-2(1H)-one; 4-(4-Fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid methyl ester; Biginelli Reaction Product; Dihydropyrimidinone derivative; DHPM derivative; Fluorophenyl DHPM ester.
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-Fluorophenyl)-6-Isopropyl-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.