Description

6-Chloro-4-oxo-1,4-dihydroquinazoline-2-carboxylic acid is a high-purity, advanced pharmaceutical intermediate with a distinct quinazoline core structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. It is essential for B2B buyers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for research, development, and scale-up manufacturing processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based drug candidates targeting various therapeutic areas.
• Oncology Research: Used in the development of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Antiviral Agent Synthesis: Serves as a building block for compounds being investigated for antiviral activity.
• Chemical Biology & Proteomics: Employed as a scaffold or probe in the study of enzyme inhibition and protein-ligand interactions.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized chemical entities.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry optimization in laboratory and pilot-scale settings.

Basic Information

Product Name	6-Chloro-4-oxo-1,4-dihydroquinazoline-2-carboxylic Acid
CAS No.	480451-49-8
Molecular Formula	C9H5ClN2O3
Molecular Weight	224.60 g/mol
Synonyms	2-Quinazolinecarboxylic acid, 6-chloro-1,4-dihydro-4-oxo-; 6-Chloro-4-oxo-1H-quinazoline-2-carboxylic acid; 6-Chloro-1,4-dihydro-4-oxoquinazoline-2-carboxylic acid; 480451-49-8; Quinazoline-2-carboxylic acid, 6-chloro-1,4-dihydro-4-oxo-; 6-Chloro-4-oxo-3,4-dihydroquinazoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-oxo-1,4-dihydroquinazoline-2-carboxylic acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.