Description

Edoxaban CAS NO 480449-70-5 is a highly potent, selective, and direct inhibitor of Factor Xa, a key enzyme in the blood coagulation cascade. This compound is of paramount importance as the active pharmaceutical ingredient (API) in anticoagulant medications used to prevent stroke and systemic embolism. It is essential for pharmaceutical manufacturers and research institutions developing and producing next-generation oral anticoagulant therapies. The consistent quality and reliable supply of this API are critical for ensuring the safety and efficacy of the final drug product.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in finished dosage forms (e.g., tablets) for anticoagulation therapy.
• Stroke Prevention in Non-Valvular Atrial Fibrillation (NVAF): Used in medications to reduce the risk of stroke and systemic embolism in patients with NVAF.
• Treatment and Prevention of Venous Thromboembolism (VTE): Applied in drugs for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrence.
• Reference Standard: Serves as a high-purity chemical standard in analytical laboratories for quality control, method development, and validation.
• Pharmacological Research: Utilized in preclinical and clinical studies to investigate mechanisms of action, pharmacokinetics, and new therapeutic applications for Factor Xa inhibitors.
• Formulation Development: Employed in R&D for developing new drug delivery systems, generic formulations, and combination therapies.

Basic Information

Product Name	Edoxaban
CAS No.	480449-70-5
Molecular Formula	C24H30ClN7O4S
Molecular Weight	548.06 g/mol
Synonyms	DU-176b; Lixiana (trade name); Savaysa (trade name); Edoxaban Tosylate; N-(5-Chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide; 1-(N-((5-Chloropyridin-2-yl)carbamoyl)-2-((5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)formamido)acetamido)-4-(dimethylcarbamoyl)cyclohexane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Edoxaban is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, typically via HPLC, IR, and other pharmacopoeial methods. We provide full traceability and support regulatory submissions with comprehensive documentation. Certificates of Analysis (COA) detailing all test results against agreed specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.