Description

Edoxaban Hydrochloride is a high-purity active pharmaceutical ingredient (API) and a potent, selective direct inhibitor of Factor Xa. This compound is critical for the development and manufacturing of anticoagulant medications, offering a targeted mechanism of action for the prevention and treatment of thromboembolic disorders. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug production and advanced pharmacological research.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of oral anticoagulant drugs.
• Reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research and development of next-generation antithrombotic agents.
• Biochemical research tool for studying coagulation pathways and Factor Xa inhibition mechanisms.
• Manufacturing of finished dosage forms, including tablets and capsules, under Good Manufacturing Practice (GMP) conditions.
• Use in preclinical and clinical studies for cardiovascular disease applications.

Basic Information

Product Name	Edoxaban Hydrochloride
CAS No.	480448-29-1
Molecular Formula	C24H30ClN7O4S • HCl
Molecular Weight	584.96 g/mol
Synonyms	Edoxaban HCl; Lixiana (trade name); Savaysa (trade name); DU-176b; N-(5-Chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide monohydrochloride; 1-(5-Chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[[5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]carbonyl]amino]cyclohexyl]-1H-pyrazole-5-carboxamide monohydrochloride
EINECS	Contact for details

Quality Control

Our Edoxaban Hydrochloride CAS NO 480448-29-1 is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality is assured through a comprehensive battery of analytical tests including HPLC for assay and purity, identification by IR and NMR spectroscopy, and严格控制 of specified impurities and residual solvents. A Certificate of Analysis (COA) documenting compliance with agreed specifications is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.