Description

7H-Pyrrolo[2,3-D]Pyrimidine, 4-Chloro-5-Iodo-7-(2,3,5-Tri-o-Benzoyl-β-D-Ribofuranosyl)- is a sophisticated nucleoside analog intermediate of significant importance in advanced pharmaceutical research and development. This compound is a key protected precursor in the synthesis of modified nucleosides, which are critical for the development of antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on nucleotide chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Antiviral Drug Research: Used in the development of nucleotide analogs targeting viral polymerases for diseases such as hepatitis and viral infections.
• Oncology Research: Serves as a precursor for creating modified nucleosides that can be incorporated into DNA/RNA to inhibit cancer cell proliferation.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate to investigate nucleoside metabolism and related pathways.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Academic & Contract Research: Essential for universities and CROs conducting cutting-edge research in medicinal chemistry and chemical biology.

Basic Information

Product Name	7H-Pyrrolo[2,3-D]Pyrimidine, 4-Chloro-5-Iodo-7-(2,3,5-Tri-o-Benzoyl-β-D-Ribofuranosyl)-
CAS No.	480439-89-2
Molecular Formula	C31H23ClIN3O7
Molecular Weight	736.89 g/mol
Synonyms	4-Chloro-5-iodo-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-iodo-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 7-(2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl)-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine; Benzoylated 4-Chloro-5-Iodo-7-Deazapurine Ribonucleoside; Protected 4-Chloro-5-Iodo-7-Deazaadenosine; 4-Cl-5-I-7-TBD-7-DAPR; Nucleoside Intermediate 480439-89-2
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical research applications. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.